Menstruation, maternity, and menopause, collectively referred to as the three M’s, affect many employees as a growing number of women participate in the labour force. However, their implications for these women’s working lives have received limited and fragmented attention in the literature. This study therefore provides the first systematic literature review integrating evidence on the impact of the three M’s on work performance and attendance. Following the SPIDER framework and PRISMA guidelines, this study systematically reviews 57 articles. Across all three M’s, findings consistently show reduced work performance, increased presenteeism, and higher absenteeism, explained by interacting biological, psychological, and contextual factors. This study also identifies important limitations in the existing literature, including the dominance of cross-sectional designs, the reliance on subjective measures, and the lack of attention to workplace solutions that address the three M’s collectively.