Federal student loan interest rates affect college financing, education and job choices, and career outcomes. Using U.S. microdata, we exploit changes in federal loan rates over time and regional variation in expected loan reliance. Higher interest rates reduce student loan take-up and the amount borrowed without raising total interest payments, and students shift toward funding sources that do not require repayment. Students facing higher borrowing costs sort into higher-earning majors and occupations, increase labor supply, and move away from self-employment and small-firm jobs. Affected individuals earn more but report lower satisfaction with job independence and responsibility.